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Extra Strength Natural Ingredients



Graminex Flower Pollen Extract
Graminex (G63™) flower pollen extract (500mg) (Secale cereal L., containing fat and water soluble fractions in a 20:1 ratio): Graminex (G63™) rye pollen in Prost-P10x has been used for 35 years in Europe for prostatitis, BPH and to support healthy prostate volume and normal nighttime urination. Unlike other pollen formulas which can lack consistency in source and quality, the Graminex in Prost-P10x is a standardized blend of (Secale cereal), corn pollen (Zea mays), and timothy pollen (Phleum pretense) which has shown success in several double-blind clinical studies to support overall prostate health. Pollen Extract and Prostate Health Studies [PDF]
  • European Urology published a randomized, multicenter, double-blind, placebo-controlled phase 3 study showing significant improvements in total symptoms related to prostate health, including comfort and overall quality of life. Eur Urol 2009 Sep; 56(3): 544-51
  • Double-blind, placebo-controlled study published in the British Journal of Urology.Cernilton had a beneficial effect on prostate health and may help promote peak urine flow. Br J Urol 1990; 66(4):398-404
  • Published Study in Urology: Pollen extract provided support for prostate health. Urology 2006 Jan; 67(1): 60-63
Meriva® Curcumin Phytosome
Meriva® Curcumin Phytosome (160mg) (Curcuma longa extract, rhizome): Studies have shown that curcumin, a naturally occurring biologically active group of compounds from Curcuma longa (turmeric), can function as efficient antioxidants and can help regulate the body's normal response to inflammatory processes. Curcumin can also play an important role in maintaining healthy angiogenic balance and help to support the body's detoxification processes. Prostate Research Labs uses a highly bioavailable curcumin called Meriva® which has been shown to have up to a 20-fold improvement in bioavailability versus the standard 95% turmeric extracts. Meriva Curcumin Extract and Prostate Health Studies [PDF]
  • International Journal of Antimicrobial Agents. A combination of curcumin, quercetin, saw palmetto, and stinging nettle was given to men who had prostatitis. Researchers reported that compared with men who received an antibiotic alone, those who took the herbal combination along with the antibiotic had significantly better resolution of their symptoms. Cai T et al: results from a prospective randomized study. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53

  • Published Studies show curcumin to be effective in managing pelvic discomfort associated with CPPS. Researchers believe curcumin is beneficial because it reduces the effect of the pro-inflammatory cytokines interleukin-8 and tumor necrosis factor alpha in the blood and tissues. Zhang QY et al. Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis. Zhonghua Nan Ke Xue 2010 Jan; 16(1): 84-88

  • Columbia University Study: Researchers noted the benefits that turmeric provided in support of prostate health in patients. Dorai T et al. Therapeutic potential of curcumin. Prostate Cancer Prostatic Dis 2000 Aug; 3(2): 84-93
Saw Palmetto Extract
Saw Palmetto Extract (640mg): The combined 640mg of saw palmetto (45% Fatty Acids) in Prost-P10x has been shown to be the most effective in studies in boosting prostate health and promoting a healthy libido. Saw Palmetto and Prostate Health Studies [PDF]

A summary of the studies relating to Saw Palmetto demonstrate the benefits of the 640mg, 45% fatty acid content in Prost-P10x particularly when used with the stinging nettle, quercetin, and curcumin combination in Prost-P10x.

  • Published results in Urology InternationalStatistically significant improvement in prostate health, quality of life, sexual function and reduction in residual urinary volume and prostate volume. Urol Int 2011

  • Clinical trial reported in Advances in Therapy – Multi-center clinical trial. The results showed that urinary and prostate health were promoted in the supplement group versus the placebo group. The researchers also reported that the prostate health-promoting activity of saw palmetto was quite significant. Adv Ther 2010 Aug; 27(8): 555-63*

  • A double-blind trial published in European Urology in 2002 indicated that saw palmetto is effective in promoting normal prostate size. Eur Urol 2002; 41(5):497-506.

  • The International Journal of Antimicrobial Agents reported on a prospective, randomized study in which 89.6 percent of men who received a combined herbal formula of saw palmetto, stinging nettle, quercetin and curcumin saw their prostate health increase significantly after the trial. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53
Quercetin Dihydrate
Quercetin Dihydrate (500mg): (flavonoid complex) Quercetin is a flavonoid found in many plants and foods, most notably red grapes, red wine, apples, tea, berries, and onions. For more than a decade, quercetin has been recognized as a potent antioxidant as well as being beneficial in supporting overall prostate health, usually at a dose of 500 mg daily. Quercetin has demonstrated in studies to provide symptomatic relief particularly when used with a saw palmetto and quercetin combination similar to that found in Prost-P10x. Quercetin and Prostate Health Studies [PDF]
  • Randomized, double-blind study published in Urology - 500 mg of quercetin twice a day for one month provided significant symptomatic improvement in men's prostate health. Urology 1999; 54(6):960-63.


  • Urology 2010 Jun; 75(6): 1249-53 - Quercetin use was associated with an increase in beneficial prostate health.
Therapeutic dosages
  • Randomized study in Molecular and Cellular Biochemistry reported that quercetin was able to positively affect the activity of specific enzymes related to prostate health. Mol Cell Biochem 2010 Nov; 344(1-2): 173-84.

  • The International Journal of Antimicrobial Agents reported on a prospective, randomized study in which 89.6 percent of men who received a combined herbal formula of saw palmetto, stinging nettle, quercetin and curcumin showed significant increase in prostate health after the trial. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53
Beta-sitosterol
Beta-sitosterol (Plant Sterols) (65mg): Beta-sitosterol appears to affect the activity of the enzyme 5-alpha-reductase, which in turn may inhibit the production of dihydrotestosterone (DHT), which in turn helps promote proper prostate size and urinary tract health. Studies have shown consistent benefits from 65 mg Prost-P10x dosage in men: Beta-Sitosterol and Prostate Health Studies [PDF]
  • Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol. The authors demonstrated an increase in maximum urine flow rate from a baseline of 9.9 mL/second to 15.2 mL/second, as well as a decrease in mean residual urinary volume. Lancet 1995; 345:1529-1532.A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol).The authors concluded that beta-sitosterol is an effective option in support of prostate health. Br J Urol 1997; 80:427-432.
  • A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol).The authors concluded that beta-sitosterol is an effective option in support of prostate health. Br J Urol 1997; 80:427-432

Green Tea
Green Tea Extract (leaf, 45% EGCG - Caffeine Free) (500mg): Green tea provides support for prostate health and normal prostate size. Green tea has also been shown in studies to regulate DHT production and hormones that influence prostate volume. The beneficial effects of taking green tea have been shown to increase with higher levels of green tea/EGCG dosage. Prost-P10x green tea extract contains 500 mg of green tea extract combining 375 mg of catechins (75%) and 450 mg (90%) total polyphenols. Green Tea and Prostate Health Studies [PDF]
  • International Journal of Urology reported on green tea studies showing improvements in prostate health. (Lee 2005) Int J Urol 2005 Apr; 12(4): 383-89

  • Numerous International Journals of Urology, Toxicology and Applied Pharmacology have reported on the effect of green tea on prostate health, normal prostate volume and the regulation of normal hormonal and enzyme activity involved in prostate and urinary health.
 
Vitamin D-3

Vitamin D-3 (1000IU): Increasing supplemental D-3 intake is associated with a trend of promoting overall prostate health. Vitamin D is widely recognized as being deficient at appropriate levels for prostate and general health. Vitamin D and Prostate Health Studies [PDF]

  • BJU International: Men who had current prostate disorders were given a daily dose of vitamin D. The authors concluded that “Vitamin D therapy is a useful addition to the therapeutic options.” (Newsom-Davis 2009)
  • Galic J, Simunovic D Prostate disorder prevalence with epidemiological and hormonal analysis in randomly selected male population in Crotia. Coll Anthropol 2008; 32(4): 1195-1202 reported finding lower levels of vitamin D in men who had BPH.
  • International Journal of Andrology: The authors pointed out that “the mechanism of action of VDR [vitamin D receptor] agonists supports an important role of chronic inflammation in BPH pathogenesis and strengthens the concept of these agents as a therapeutic option for pharmacological treatment of BPH.” (Fibbi B et al. Chronic inflammation in the pathogenesis of benign prostatic hyperplasia. Int J Androl 2010 Jun 1; 33(3): 475-88)
  • The Journal of Autoimmunity recently published a study on prostatitis and vitamin D which concluded that “vitamin D receptor modulation holds the promise of interfering with autoimmune prostatitis.” (Motrich 2009)
 
3,3-Diindolylmethane (DIM)

3,3-Diindolylmethane (DIM) (100mg):As men age, they experience a decline in testosterone and, in many cases, increases in estrogen levels. The result is a testosterone/ estrogen imbalance that emerging research suggest may impact overall prostate health. Unique to Prost-P10x in this formulation, DIM naturally supports the testosterone/estrogen balance as well as promoting sexual energy and normal prostate size. In a safety study of both I3C and DIM, supplementation with absorbable DIM resulted in reports of an improvement in prostate function, based on a reduction in nighttime urination, in older men with symptoms of an aging prostate. (Zeligs) DIM and Prostate Health Studies [PDF]

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Cranberry
Cranberry (Vaccinum macrocapron, fruit) (500mg): Cranberry provides natural support for urinary tract health as well as providing prostate health support. In 2004, France became the first country to approve a health claim for the American cranberry for urinary tract health. A powder based cranberry supplementation at 500 mg can provide significant improvement in prostate health clinical scores based on reported studies: Cranberry and Prostate Health Studies [PDF]
  • The British Journal of Nutrition reported cranberries may help support prostate health as well as a reduction in C-reactive protein levels. Vidlar A et al. The effectiveness of dried cranberries (Vaccinium macrocarpon) in men in supporting prostate health. Br J Nutr 2010 Oct; 104(8): 1181-89
  • British Journal of Nutrition in the same article also reported on statistically significant improvement in Prostate Health Scores, quality of life and urination factors (e.g., rate of urine flow, average flow, total volume, post-void residual urine volume). Br J Nutr 2010 Oct; 104(8): 1181-89
  • The Journal of Infections and Chemotherapy reported on a study showing the beneficial effects of cranberry on prostate health. Kim SH et al. Do J Infect Chemother 2010 Nov 2
Stinging Nettle
Stinging Nettle (root) (240mg): Stinging Nettle Root may help with the management of urinary tract and volume related to an aging prostate particularly when used with the saw palmetto and quercetin combination in Prost-P10x. The Nettle root provides prostate and urinary tract support and potentially can naturally interact with the binding of DHT providing a further mechanism of action for supporting prostate health. Stinging Nettle and Prostate Health Studies [PDF]
  • Six-month, double-blind, placebo-controlled, randomized comparative trial on the effectiveness of stinging nettle on prostate health. 81 percent of men reported an improvement in lower urinary tract health J Herb Pharmacother 2005; 5(4):1-11
  • Published report in Urologe. Randomized, double-blind, placebo-controlled multicenter study in men reported improved prostate and urinary tract health. Schneider T, Rubben H.. Urologe A 2004 Mar; 43(3): 302-6
  • The International Journal of Antimicrobial Agents reported on a prospective, randomized study in which 89.6 percent of men who received a combined herbal formula of saw palmetto, stinging nettle (root), quercetin and curcumin had no symptoms of prostatitis after the trial. Int J Antimicrob Agents 2009 Jun; 33(6): 549-5
Pygeum africanum
Pygeum africanum (bark) (CITES certified for sustainable farming practices) (100mg): Pygeum is an herbal remedy derived from the bark of the Pygeum africanum tree that has been used since ancient times to promote bladder health. The major active components of the bark are fat-soluble sterols (phytosterols) and fatty acids that can inhibit the production of DHT (dihydrotestosterone), a hormone that is related to prostate health. Pygeum also may reduce the number of receptor sites where DHT can attach to cells. Numerous studies have supported the use of Pygeum in the management of prostate health: Pygeum and Prostate Health Studies [PDF]
  • Journal of Urology reported on a study where the authors concluded that the therapeutic effect of Pygeum africanum may be due at least in part to the inhibition of growth factors responsible for maintaining prostate health. J Urol 1997; 157:2381-87

    CITES certified: Ingredients Sourced from Sustainable Plantations.
  • Current Medical Research and Opinion reported on a study in which the authors concluded that under conditions of daily practice, Pygeum africanum extract induces significant improvement in prostate health and uroflowmetry parameters. Breza J et al.. Curr Med Res Opin 1998; 14(3):127-39.
Zinc
Zinc (as Zinc Citrate - Non-Seafood/Non-Animal) (15mg): Zinc is known to promote sexual function as well as to promote prostate health. The mineral is also a key support player in the body's DNA-damage repair process. In addition to its role in proper sexual development and reproduction, zinc helps promote a strong immune system, aids in memory health, supports healthy cholesterol levels and assists in maintaining healthy blood pressure. Zinc and Prostate Health Studies [PDF]
  • University of Washington Prevention Program Study saw a decreased risk of advanced prostate decline with a greater intake of supplemental zinc (Gonzalez A et al. Nutr Cancer 2009; 61(2):206-215.)

  • Researchers have found that zinc concentrations in men who had prostatitis were lower than those in control groups used in the studies. This finding led them to "consider the possibility of recommending zinc supplements as a coadjuvant therapy in patients with prostatitis". (Gomez Y et al. Zinc levels in prostatic fluid of patients with prostate pathologies.Invest Clin 2007 Sep; 48(3): 287-94).

  • Oregon State University Study concluded that the differential response to zinc in the prostate cancer and BPH cells "suggests that zinc may serve an important role in regulating cell growth and apoptosis in hyperplasia cells." (Yan 2010) Yan M et al. Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cells. J Nutr Biochem 2010 Aug; 21(8): 687-94

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